Controlled Delivery of Bile Acids to the Colon
نویسندگان
چکیده
منابع مشابه
Secondary bile acids: an underrecognized cause of colon cancer
Bile acids were first proposed as carcinogens in 1939. Since then, accumulated evidence has linked exposure of cells of the gastrointestinal tract to repeated high physiologic levels of bile acids as an important risk factor for gastrointestinal cancers. High exposure to bile acids may occur in a number of settings, but most importantly, is prevalent among individuals who have a high dietary fa...
متن کاملBiliary bile acids in cholelithiasis and colon cancer.
The role of biliary deoxycholate as an endogenous colon carcinogen and the possible association between cholelithiasis and/or cholecystectomy and the subsequent development of large bowel cancer is unclear. This paper describes biliary bile acids analysis performed on 13 patients undergoing cholecystectomy for gall stones, 10 patients undergoing colonic resection for colon cancer, and eight con...
متن کاملHydrophobic bile acids, genomic instability, Darwinian selection, and colon carcinogenesis
Sporadic colon cancer is caused predominantly by dietary factors. We have selected bile acids as a focus of this review since high levels of hydrophobic bile acids accompany a Western-style diet, and play a key role in colon carcinogenesis. We describe how bile acid-induced stresses cause cell death in susceptible cells, contribute to genomic instability in surviving cells, impose Darwinian sel...
متن کاملBile Acids: Promoters or Carcinogens in Colon Cancer?
Copyright: © 2011 Bernstein C, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Since the 1970s it has been generally considered that bile acids are promoters of colon cancer, but lack carcinogenic activ...
متن کاملSecondary bile acids effects in colon pathology. Experimental mice study.
PURPOSE To assess whether deoxycholic acid (DOC) and lithocholic acid (LCA) administered in a period of six months in a concentration of 0.25% may have a carcinogenic role in mice colon. METHODS The study used C57BL6 female mice divided into four groups. The control group received a balanced diet and the others received diets supplemented with 0.25% DOC, 0.25% LCA and 0.125% DOC+0.125% LCA, r...
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ژورنال
عنوان ژورنال: Clinical and Translational Gastroenterology
سال: 2020
ISSN: 2155-384X
DOI: 10.14309/ctg.0000000000000229